TRAF1 抗体 (AA 73-219)
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- 抗原 See all TRAF1 抗体
- TRAF1 (TNF Receptor-Associated Factor 1 (TRAF1))
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抗原表位
- AA 73-219
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TRAF1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Staining Methods (StM)
- 特异性
- This MAb recognizes a protein of 52 kDa, which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30 % of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously, whereas those of cALCL persist and may progress and spread. Moreover, LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach, in contrast to patients with cALCL. Besides, LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR)-associated factor 1), a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84 %) show a strong TRAF1 expression, tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7 %). Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant fragment of human TRAF1 protein (around aa 73-219) (exact sequence is proprietary)
- 克隆位点
- TRAF1-2770
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product TRAF1 Primary Antibody
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anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 301-416) antibody
TRAF1 适用: 人, 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1A6 unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (C-Term) antibodyVerified TRAF1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 131-381) antibodyTRAF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 73-219) antibodyTRAF1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal TRAF1-3298 unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2G9-G10 unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (C-Term) antibodyTRAF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 217-416) antibodyTRAF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Positive Control: HeLa or 293T cells. Hodgkin s Lymphoma (IHC).
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- TRAF1 (TNF Receptor-Associated Factor 1 (TRAF1))
- 别名
- TRAF1 (TRAF1 产品)
- 别名
- CG3048 antibody, DTRAF antibody, DTRAF1 antibody, Dmel\\CG3048 antibody, TRAF antibody, TRAF1 antibody, Traf1 antibody, dTRAF antibody, dTRAF1 antibody, dTraf1 antibody, dtraf1 antibody, traf1 antibody, traf4 antibody, DKFZp469G032 antibody, EBI6 antibody, MGC:10353 antibody, 4732496E14Rik antibody, TNF receptor associated factor 1 antibody, TNF-receptor-associated factor 4 antibody, TNF receptor-associated factor 1 antibody, TRAF1 antibody, Traf4 antibody, Traf1 antibody, traf1 antibody
- 分子量
- 52kDa
- 基因ID
- 7185
- UniProt
- Q13077
- 途径
- NF-kappaB Signaling, Apoptosis, Cell-Cell Junction Organization, Asymmetric Protein Localization
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