MMP14 抗体 (AA 145-174)
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北京 101111
Quick Overview for MMP14 抗体 (AA 145-174) (ABIN7870722)
抗原
See all MMP14 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 145-174
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原理
- MMP14 Antibody
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 145-174 from the human protein was used as the immunogen for the MMP14 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the MMP14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the MMP14 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))
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别名
- MMP14
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背景
- Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.
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UniProt
- P50281
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途径
- Autophagy
抗原
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