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RAD51 抗体 (AA 1-134)

The 小鼠 单克隆 anti-RAD51 antibody is suitable to detect RAD51 in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7868112
发货至: 中国
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Quick Overview for RAD51 抗体 (AA 1-134) (ABIN7868112)

抗原

See all RAD51 抗体
RAD51 (DNA Repair Protein Homolog 1 (RAD51))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This RAD51 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RALPA-1
  • 抗原表位

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    AA 1-134

    原理

    RAD51 Antibody

    纯化方法

    Protein G affinity chromatography

    免疫原

    A portion of amino acids 1-134 from the human protein was used as the immunogen for this RAD51 antibody.

    亚型

    IgG2b, kappa
  • 应用备注

    The stated application concentrations are suggested starting points. Titration of the RAD51 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store the RAD51 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    RAD51 (DNA Repair Protein Homolog 1 (RAD51))

    别名

    RAD51

    背景

    The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [RefSeq]

    UniProt

    Q06609

    途径

    DNA Damage Repair
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