RAD51 抗体 (AA 1-134)
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北京 101111
Quick Overview for RAD51 抗体 (AA 1-134) (ABIN7868109)
抗原
See all RAD51 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-134
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原理
- RAD51 Antibody
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纯化方法
- Protein G affinity chromatography
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免疫原
- A portion of amino acids 1-134 from the human protein was used as the immunogen for this RAD51 antibody.
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亚型
- IgG1, kappa
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anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-339) antibody
RAD51 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (Center) antibodyRAD51 适用: 人, 小鼠 WB, IP, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) antibodyKD Validated RAD51 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 23GB4600 unconjugated Recombinant Antibody
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 81-180) antibodyRAD51 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-242) antibodyRAD51 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E5-E5 unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-339) antibodyRAD51 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-134) antibodyRAD51 适用: 人 IHC, FACS 宿主: 小鼠 Monoclonal RAD51-2702 unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-134) antibodyRAD51 适用: 人 WB, IHC, FACS 宿主: 小鼠 Monoclonal RAD51-2701 unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-228) antibodyRAD51 适用: 人 WB, IHC, ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-258) antibodyRAD51 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Optimal dilution of the RAD51 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min. -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the RAD51 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- RAD51 (DNA Repair Protein Homolog 1 (RAD51))
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别名
- RAD51
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背景
- RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies. RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma.
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UniProt
- Q06609
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途径
- DNA Damage Repair
抗原
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