IL-6 抗体 (AA 1-193)
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北京 101111
Quick Overview for IL-6 抗体 (AA 1-193) (ABIN7858342)
抗原
See all IL-6 (IL6) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-193
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原理
- IL-6 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody
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特异性
- Four structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1±, IL-1≤ and IL-1≥/IL-18 and a specific receptor antagonist, IL-1R±. IL-1± and IL-1≤ play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1≥) has been shown to augment the secretion of IFN-≥ from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19 % and 12 % identity with IL-1± and IL-1≤ respectively over the 12 ≤-strands of the ≤-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1≤ pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-≥-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Recombinant fragment (around aa1-193) of human IL-18 protein (exact sequence is proprietary)
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亚型
- IgG2, kappa
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anti-Interleukin 6 (IL6) (AA 111-150) antibody
IL6 适用: 人, 小鼠, 大鼠, 兔, Cow WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 (IL6) antibodyIL6 适用: 人 ELISA, FACS, Func, ELISpot 宿主: 小鼠 Monoclonal B-E8 unconjugated
anti-Interleukin 6 (IL6) (AA 21-211) antibodyIL6 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Interleukin 6 (IL6) (AA 27-212) antibodyIL6 适用: 猕猴 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 18# unconjugated
anti-Interleukin 6 (IL6) (AA 21-211) antibodyIL6 适用: 大鼠 WB, IHC, IP, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Interleukin 6 (IL6) (AA 101-150) antibodyIL6 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 (IL6) (AA 27-241) antibodyIL6 适用: 兔 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C506 unconjugated
anti-Interleukin 6 (IL6) (AA 25-211) antibodyIL6 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 (IL6) (AA 27-55) antibodyIL6 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 (IL6) (AA 26-50) antibodyIL6 适用: 人, 大鼠 ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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- IL-6 (IL6) (Interleukin 6 (IL6))
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别名
- IL-6
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背景
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Iboctadekin, IFN gamma inducing factor, IGIF, IL1 gamma, IL18, IL18 protein, IL1F4, IL1g, IL1gamma, Interleukin 18, Interleukin-1 gamma, MGC12320
A549 cells, Human heart or adrenal gland. Stimulated peritoneal macrophages.
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分子量
- 18kDa
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基因ID
- 3606, 83077
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UniProt
- Q14116
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途径
- TLR signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
抗原
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