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Recombinant KAT2B 抗体

This 兔 单克隆 antibody specifically detects KAT2B in WB 和 IP. It exhibits reactivity toward 人.
产品编号 ABIN7828333
发货至: 中国
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中国
北京 101111
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Beijing Economic Technological Development Area
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Quick Overview for Recombinant KAT2B 抗体 (ABIN7828333)

抗原

See all KAT2B 抗体
KAT2B (K(lysine) Acetyltransferase 2B (KAT2B))

抗体类型

Recombinant Antibody

适用

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宿主

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克隆类型

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单克隆

标记

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This KAT2B antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP)

克隆位点

A271
  • 原理

    Recombinant PCAF Monoclonal Antibody

    纯化方法

    Protein A purified

    免疫原

    Recombinant human PCAF fragment

    亚型

    IgG, kappa
  • 应用备注

    WB 1:500-1:1000,IP 1:25-1:50

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

    有效期

    12 months
  • 抗原

    KAT2B (K(lysine) Acetyltransferase 2B (KAT2B))

    别名

    PCAF

    背景

    KAT2B,CAF,P/CAF,PCAF,Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4, RRP9/U3-55K and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing. Also acetylates spermidine. (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

    分子量

    Calculated MW: 93 kDa

    Observed MW: 93 kDa

    UniProt

    Q92831

    途径

    p53 Pathway, Regulation of Carbohydrate Metabolic Process
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