FGFR3 抗体 (Middle Region)
Quick Overview for FGFR3 抗体 (Middle Region) (ABIN7603047)
抗原
See all FGFR3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- Anti-FGFR3 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-FGFR3 Antibody Picoband® (ABIN7603047). Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human FGFR3.
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亚型
- IgG
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anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 529-694) antibody
FGFR3 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2H10B4 unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 166-375) antibodyFGFR3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 39-138) antibodyFGFR3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 23-375) antibodyFGFR3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (C-Term) antibodyFGFR3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 529-694) antibodyFGFR3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 1E3F9 unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) antibodyFGFR3 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 131-180) antibodyFGFR3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 776-806) antibodyFGFR3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 3 (FGFR3) (AA 468-495) antibodyFGFR3 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
1. Almeida, M. R., Campos-Xavier, A. B., Medeira, A., Cordeiro, I., Sousa, A. B., Lima, M., Soares, G., Rocha, M., Saraiva, J., Ramos, L., Sousa, S., Marcelino, J. P., Correia, A., Santos, H. G. Clinical and molecular diagnosis of the skeletal dysplasias associated with mutations in the gene encoding fibroblast growth factor receptor 3 (FGFR3) in Portugal. Clin. Genet. 75: 150-156, 2009. 2. Barroso, E., Perez-Carrizosa, V., Garcia-Recuero, I., Glucksman, M. J., Wilkie, A. O., Garcia-Minaur, S., Heath, K. E. Mild isolated craniosynostosis due to a novel FGFR3 mutation, p.Ala334Thr. Am. J. Med. Genet. 155A: 3050-3053, 2011. -
限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
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At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
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- FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
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别名
- FGFR3
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背景
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Synonyms: Toll-like receptor 3, CD283, TLR3
Tissue Specificity: Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
Background: Fibroblast growth factor receptor 3, also known as CD333, is a protein that in humans is encoded by the FGFR3 gene. This gene encodes a member of the fibroblast growth factor receptor(FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. The FGFR3 gene is mapped to the HD region on chromosome 4p16.3. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
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分子量
- 100 kDa
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基因ID
- 2261
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UniProt
- P22607
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding
抗原
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