Presenilin 2 抗体 (AA 275-325)
Quick Overview for Presenilin 2 抗体 (AA 275-325) (ABIN7455024)
抗原
See all Presenilin 2 (PSEN2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 275-325
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原理
- Rabbit anti-Presenilin-2 Antibody, Affinity Purified
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预测反应
- Mouse,Rat,Bovine,Pig,Orangutan
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纯化方法
- Affinity Purified
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免疫原
- Between AA 275 and 325
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亚型
- IgG
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应用备注
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: 1:1,000 - 1:5,000
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
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别名
- Presenilin-2
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背景
- Background: Presenilin-2 is a probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Presenilin-2 requires the other members of the gamma-secretase complex to have a protease activity. It may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may function in the cytoplasmic partitioning of proteins [taken from the Universal Protein Resource (UniProt) P49810].
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基因ID
- 5664
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NCBI登录号
- NP_000438
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UniProt
- P49810
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途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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