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Presenilin 2 抗体 (AA 275-325)

This anti-Presenilin 2 antibody is a 兔 多克隆 antibody detecting Presenilin 2 in WB, IP 和 IHC (fp). Suitable for 人.
产品编号 ABIN7455024
发货至: 中国
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Quick Overview for Presenilin 2 抗体 (AA 275-325) (ABIN7455024)

抗原

See all Presenilin 2 (PSEN2) 抗体
Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

适用

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宿主

  • 52
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克隆类型

  • 58
  • 5
多克隆

标记

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This Presenilin 2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))
  • 抗原表位

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    AA 275-325

    原理

    Rabbit anti-Presenilin-2 Antibody, Affinity Purified

    预测反应

    Mouse,Rat,Bovine,Pig,Orangutan

    纯化方法

    Affinity Purified

    免疫原

    Between AA 275 and 325

    亚型

    IgG
  • 应用备注

    IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    IP: 2 - 10 μg/mg lysate

    WB: 1:1,000 - 1:5,000

    限制

    仅限研究用
  • 浓度

    1000 μg/mL

    缓冲液

    Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    有效期

    12 months
  • 抗原

    Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

    别名

    Presenilin-2

    背景

    Background: Presenilin-2 is a probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Presenilin-2 requires the other members of the gamma-secretase complex to have a protease activity. It may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may function in the cytoplasmic partitioning of proteins [taken from the Universal Protein Resource (UniProt) P49810].

    基因ID

    5664

    NCBI登录号

    NP_000438

    UniProt

    P49810

    途径

    Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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