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- 抗原 See all Presenilin 2 (PSEN2) 抗体
- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
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适用
- 人, 大鼠, 小鼠, 犬
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Presenilin 2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 纯化方法
- Affinity purified
- 免疫原
- Presenilin 2 antibody was raised using a synthetic peptide corresponding to a region with amino acids VVVATIKSVRFYTEKNGQLIYTPFTEDTPSVGQRLLNSVLNTLIMISVIV
- Top Product
- Discover our top product PSEN2 Primary Antibody
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anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (N-Term) antibody
PSEN2 适用: 人, 大鼠, 小鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) antibodyPSEN2 适用: 人, 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 39-51), (N-Term) antibodyPSEN2 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (N-Term) antibodyPSEN2 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 33-48), (Intracellular), (N-Term) antibodyPSEN2 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 319-334) antibodyPSEN2 适用: 人, 大鼠 WB, IHC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 101-150) antibodyPSEN2 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 猴, Bat, Hamster, Pig, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 32-65), (N-Term) antibodyPSEN2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB30801 unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 7-77) antibodyPSEN2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 32-65) antibodyPSEN2 适用: 人 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: 1 µg/mL, IHC: 4-8 µg/mL
Optimal conditions should be determined by the investigator. - 说明
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Presenilin 2 Blocking Peptide, catalog no. 33R-9902, is also available for use as a blocking control in assays to test for specificity of this Presenilin 2 antibody
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of PSEN2 antibody in PBS
- 浓度
- Lot specific
- 缓冲液
- PBS
- 注意事项
- Avoid repeated freeze/thaw cycles.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
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- 抗原
- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
- 别名
- Presenilin 2 (PSEN2 产品)
- 别名
- AD3L antibody, AD4 antibody, CMD1V antibody, PS2 antibody, STM2 antibody, ALG-3 antibody, Ad4h antibody, Alg3 antibody, PS-2 antibody, Psnl2 antibody, pre2 antibody, zf-PS2 antibody, PSNL2 antibody, PSEN2 antibody, ad4 antibody, ps2 antibody, ad3l antibody, stm2 antibody, Ps2 antibody, presenilin 2 antibody, presenilin 2 S homeolog antibody, presenilin 2 (Alzheimer disease 4) antibody, trefoil factor 1 antibody, PSEN2 antibody, Psen2 antibody, psen2 antibody, psen2.S antibody, Tff1 antibody
- 背景
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.
- 分子量
- 49 kDa (MW of target protein)
- 途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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