Retinoblastoma 1 抗体 (AA 550-600)
Quick Overview for Retinoblastoma 1 抗体 (AA 550-600) (ABIN7449625)
抗原
See all Retinoblastoma 1 (RB1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 550-600
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原理
- Rabbit anti-Rb1 Antibody, Affinity Purified
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纯化方法
- Affinity Purified
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免疫原
- between AA 550 and 600
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亚型
- IgG
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应用备注
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IP: 10 - 15 μg/mg lysate
WB: Not recommended.
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限制
- 仅限研究用
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浓度
- 1000 μg/mL
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缓冲液
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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有效期
- 12 months
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- Retinoblastoma 1 (RB1)
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别名
- Rb1
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背景
- Background: Retinoblastoma 1 (Rb1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. Rb1 has also been found to stabilize constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma [taken from NCBI Entrez Gene (GeneID: 5925)].
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基因ID
- 5925
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NCBI登录号
- NP_000312
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UniProt
- P06400
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途径
- Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy
抗原
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