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MHC Class II HLA-DP/DQ/DR 抗体

This anti-MHC Class II HLA-DP/DQ/DR antibody is a 小鼠 单克隆 antibody detecting MHC Class II HLA-DP/DQ/DR in WB, IHC 和 ICC. Suitable for 人.
产品编号 ABIN7449429
发货至: 中国

Quick Overview for MHC Class II HLA-DP/DQ/DR 抗体 (ABIN7449429)

抗原

MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

适用

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宿主

  • 26
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小鼠

克隆类型

  • 37
单克隆

标记

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This MHC Class II HLA-DP/DQ/DR antibody is un-conjugated

应用范围

  • 35
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Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

克隆位点

CR3-43
  • 原理

    Mouse anti-HLA-DR/DP/DQ Monoclonal Antibody [CR3/43]

    纯化方法

    Purified

    免疫原

    Cells from human tonsil

    亚型

    IgG1
  • 应用备注

    IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

    ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.

    WB: 01:01,00

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    250 μg/mL

    缓冲液

    Phosphate Buffered Saline (PBS) with 0.1 % BSA and 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    2 - 8 °C

    有效期

    12 months
  • 抗原

    MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)

    别名

    HLA-DR/DP/DQ

    背景

    In humans, Major Histocompatibility Locus (MHC) class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display ~70 % similarity to each other. Polymorphism is a notable feature of MHC class II genes. HLA-DR, HLA-DP, and HLA-DQ are heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. Variations in the HLA gene expression are crucial to graft survival.

    基因ID

    3122

    UniProt

    P01903

    途径

    Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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