MHC Class II HLA-DP/DQ/DR 抗体
Quick Overview for MHC Class II HLA-DP/DQ/DR 抗体 (ABIN7449429)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Mouse anti-HLA-DR/DP/DQ Monoclonal Antibody [CR3/43]
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纯化方法
- Purified
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免疫原
- Cells from human tonsil
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亚型
- IgG1
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应用备注
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IHC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
ICC: 1:100 to 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections.
WB: 01:01,00
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Phosphate Buffered Saline (PBS) with 0.1 % BSA and 0.09 % Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- 2 - 8 °C
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有效期
- 12 months
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- MHC Class II HLA-DP/DQ/DR (HLA-DP/DQ/DR)
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别名
- HLA-DR/DP/DQ
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背景
- In humans, Major Histocompatibility Locus (MHC) class II molecules are encoded by three different loci, HLA-DR, -DQ, and -DP, which display ~70 % similarity to each other. Polymorphism is a notable feature of MHC class II genes. HLA-DR, HLA-DP, and HLA-DQ are heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 Molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. Variations in the HLA gene expression are crucial to graft survival.
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基因ID
- 3122
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UniProt
- P01903
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途径
- Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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