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- 抗原 See all NSMCE1 抗体
- NSMCE1 (Non-SMC Element 1 Homolog (NSMCE1))
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抗原表位
- AA 7-266
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NSMCE1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 原理
- NSMCE1 Rabbit pAb
- 序列
- RMGVMTDVHR RFLQLLMTHG VLEEWDVKRL QTHCYKVHDR NATVDKLEDF INNINSVLES LYIEIKRGVT EDDGRPIYAL VNLATTSISK MATDFAENEL DLFRKALELI IDSETGFASS TNILNLVDQL KGKKMRKKEA EQVLQKFVQN KWLIEKEGEF TLHGRAILEM EQYIRETYPD AVKICNICHS LLIQGQSCET CGIRMHLPCV AKYFQSNAEP RCPHCNDYWP HEIPKVFDPE KERESGVLKS NKKSLRSRQH
- 交叉反应
- 人, 大鼠
- 产品特性
- Polyclonal Antibodies
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 7-266 of human NSMCE1 (NP_659547.2).
- 亚型
- IgG
- Top Product
- Discover our top product NSMCE1 Primary Antibody
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anti-Non-SMC Element 1 Homolog (NSMCE1) (AA 1-256) antibody
NSMCE1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Non-SMC Element 1 Homolog (NSMCE1) (Center) antibodyNSMCE1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Non-SMC Element 1 Homolog (NSMCE1) antibodyNSMCE1 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Non-SMC Element 1 Homolog (NSMCE1) (AA 81-130) antibodyNSMCE1 适用: 人, 大鼠, 小鼠, 豚鼠, 兔, 斑马鱼, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Non-SMC Element 1 Homolog (NSMCE1) (AA 143-192) antibodyNSMCE1 适用: 人, 大鼠, 小鼠, 豚鼠, Cow, 山羊, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB,1:500 - 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- 抗原
- NSMCE1 (Non-SMC Element 1 Homolog (NSMCE1))
- 别名
- NSMCE1 (NSMCE1 产品)
- 别名
- zgc:92777 antibody, NSMCE1 antibody, NSE1 antibody, 2510027N19Rik antibody, RGD1307760 antibody, NSE1 homolog, SMC5-SMC6 complex component antibody, NSE1 homolog, SMC5-SMC6 complex component L homeolog antibody, nsmce1 antibody, NSMCE1 antibody, nsmce1.L antibody, Nsmce1 antibody
- 背景
- RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors.,NSMCE1,NSE1,NSE1 homolog,Epigenetics & Nuclear Signaling,DNA Damage & Repair,NSMCE1
- 分子量
- 30kDa
- 基因ID
- 197370
- UniProt
- Q8WV22
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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