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Lamin A/C 抗体

This anti-Lamin A/C antibody is a 兔 单克隆 antibody detecting Lamin A/C in WB, IHC, IF 和 IP. Suitable for 人.
产品编号 ABIN7268177
发货至: 中国

Quick Overview for Lamin A/C 抗体 (ABIN7268177)

抗原

See all Lamin A/C (LMNA) 抗体
Lamin A/C (LMNA)

适用

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宿主

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克隆类型

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单克隆

标记

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This Lamin A/C antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

质量等级

KO Validated
  • 原理

    [KO Validated] Lamin A/C Rabbit mAb

    交叉反应

    人, 小鼠, 大鼠

    产品特性

    Monoclonal Antibodies

    纯化方法

    Affinity purification

    免疫原

    Recombinant protein of human Lamin A/C.

    亚型

    IgG
  • 应用备注

    WB,1:50000 - 1:200000,IHC,1:50 - 1:1000,IF,1:50 - 1:1000,IP,1:50 - 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原

    Lamin A/C (LMNA)

    别名

    LMNA

    背景

    The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.,LMNA,CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,FPLD2,HGPS,IDC,LDP1,LFP,LGMD1B,LMN1,LMNC,LMNL1,MADA,PRO1,lamin,Lamin A/C,Apoptosis,Cell Biology & Developmental Biology,Cell Cycle,Cytoskeleton,Cytoskeleton_Intermediate Filaments,Death Receptor Signaling Pathway,PI3K-Akt Signaling Pathway,Protein folding,Protein phosphorylation,Signal Transduction,Stem Cells,LMNA

    分子量

    62-74kDa

    基因ID

    4000

    UniProt

    P02545

    途径

    Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
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