BRAF 抗体 (AA 350-449)
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北京 101111
Quick Overview for BRAF 抗体 (AA 350-449) (ABIN7265818)
抗原
See all BRAF 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 350-449
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原理
- B-Raf Rabbit pAb
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序列
- DEDHRNQFGQ RDRSSSAPNV HINTIEPVNI DDLIRDQGFR GDGGSTTGLS ATPPASLPGS LTNVKALQKS PGPQRERKSS SSSEDRNRMK TLGRRDSSDD
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 350-449 of human B-Raf (NP_004324.2).
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- BRAF (B-Raf proto-oncogene, serine/threonine kinase (BRAF))
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别名
- BRAF
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背景
- This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.,BRAF,B-RAF1,B-raf,BRAF1,NS7,RAFB1,Cancer,Signal Transduction,G protein signaling,G2/M DNA Damage Checkpoint,Kinase,Serine/threonine kinases,Tyrosine kinases,ErbB-HER Signaling Pathway,MAPK-Erk Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Inhibition of Apoptosis,Cell Cycle,Cell differentiation,ESC Pluripotency and Differentiation,Immunology & Inflammation,T Cell Receptor Signaling Pathway,IL-6 Receptor Signaling Pathway,Neuroscience,BRAF
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分子量
- 84kDa
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基因ID
- 673
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UniProt
- P15056
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途径
- MAPK Pathway, RTK signaling, Neurotrophin Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Hepatitis C, Autophagy
抗原
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