Retinoblastoma Binding Protein 8 抗体
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Quick Overview for Retinoblastoma Binding Protein 8 抗体 (ABIN7223948)
抗原
See all Retinoblastoma Binding Protein 8 (RBBP8) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- CtIP Polyclonal Antibody
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特异性
- CtIP Polyclonal Antibody detects endogenous levels of CtIP protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human CtIP around the non-phosphorylation site of S664
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亚型
- IgG
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- Retinoblastoma Binding Protein 8 (RBBP8)
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别名
- CtIP
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背景
- Rabbit Anti-CtIP Polyclonal Antibody,RBBP8, CTIP, DNA endonuclease RBBP8, CtBP-interacting protein, CtIP, Retinoblastoma-binding protein 8, RBBP-8, Retinoblastoma-interacting protein and myosin-like, RIM, Sporulation in the absence of SPO11 protein 2 homolog, SAE2,The protein encoded by RBBP8 (RB binding protein 8, endonuclease) is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that RBBP8 may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for RBBP8. More transcript variants exist, but their full-length natures have not been determined.,DNA endonuclease RBBP8
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基因ID
- 5932
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UniProt
- Q99708
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途径
- Cell Division Cycle, DNA Damage Repair
抗原
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