Presenilin 2 抗体 (pSer330)
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Quick Overview for Presenilin 2 抗体 (pSer330) (ABIN7223662)
抗原
See all Presenilin 2 (PSEN2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer330
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原理
- Presenilin 2 (phospho Ser330) Polyclonal Antibody
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特异性
- Phospho-Presenilin 2 (S330) Polyclonal Antibody detects endogenous levels of Presenilin 2 protein only when phosphorylated at S330.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
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免疫原
- Synthesized peptide derived from human Presenilin 2 Phospho-Ser330
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亚型
- IgG
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anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) antibody
PSEN2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 39-51), (N-Term) antibodyPSEN2 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (N-Term) antibodyPSEN2 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 33-48), (Intracellular) antibodyPSEN2 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 319-334) antibodyPSEN2 适用: 人, 大鼠 WB, IHC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 101-150) antibodyPSEN2 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 猴, Bat, Hamster, Pig, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) antibodyPSEN2 适用: 人, 大鼠, 小鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 32-65), (N-Term) antibodyPSEN2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB30801 unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 7-77) antibodyPSEN2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 32-65) antibodyPSEN2 适用: 人 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.
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说明
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Primary Antibody
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
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别名
- Presenilin 2
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背景
- Rabbit Anti-Presenilin 2 (phospho Ser330) Polyclonal Antibody,PSEN2, AD4, PS2, PSNL2, STM2, Presenilin-2, PS-2, AD3LP, AD5, E5-1, STM-2,Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.,Presenilin-2
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分子量
- observerd band 50kDa
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基因ID
- 5664
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UniProt
- P49810
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途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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