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- 抗原 See all MLKL 抗体
- MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
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抗原表位
- pSer358
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MLKL antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- 原理
- phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8)
- 特异性
- Phospho-MLKL (S358) protein detects endogenous levels of MLKL.
- 纯化方法
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen
- 免疫原
- Synthetic Peptide of phospho-MLKL (S358)
- 克隆位点
- 6F8
- 亚型
- IgG1
- Top Product
- Discover our top product MLKL Primary Antibody
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anti-Mixed Lineage Kinase Domain-Like (MLKL) antibody
MLKL 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (AA 371-471) antibodyMLKL 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 3B2 unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (Internal Region) antibodyMLKL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (AA 444-472) antibodyMLKL 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (AA 1-471) antibodyMLKL 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (C-Term) antibodyMLKL 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (pSer358) antibodyMLKL 适用: 人 IHC (p) 宿主: 小鼠 Monoclonal 6E3 unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) antibodyMLKL 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) (AA 371-472) antibodyMLKL 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 3B2 unconjugated
anti-Mixed Lineage Kinase Domain-Like (MLKL) antibodyMLKL 适用: 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:100-1:200).
- 说明
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Primary Antibody
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
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- 抗原
- MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
- 别名
- MLKL (MLKL 产品)
- 别名
- MLKL antibody, 9130019I15Rik antibody, mixed lineage kinase domain like pseudokinase antibody, mixed lineage kinase domain-like antibody, MLKL antibody, mlkl antibody, Mlkl antibody
- 背景
- Mouse Anti-phospho-MLKL (S358) Mouse Monoclonal Antibody (6F8),MLKL,MLKL (mixed lineage kinase domain like) belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of MLKL inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for MLKL.,MLKL
- 分子量
- observerd band 54kDa
- 基因ID
- 197259
- UniProt
- Q8NB16
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