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MLKL 抗体

MLKL 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7259674
发货至: 中国
  • 抗原 See all MLKL 抗体
    MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
    适用
    • 58
    • 40
    • 17
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 69
    • 8
    克隆类型
    • 61
    • 16
    多克隆
    标记
    • 35
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    This MLKL antibody is un-conjugated
    应用范围
    • 34
    • 29
    • 14
    • 11
    • 7
    • 5
    • 1
    • 1
    Immunohistochemistry (IHC)
    产品特性
    Polyclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein of mouse MLKL
    亚型
    IgG
  • 应用备注
    IHC 1:50-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
    别名
    MLKL (MLKL 产品)
    别名
    MLKL antibody, 9130019I15Rik antibody, mixed lineage kinase domain like pseudokinase antibody, mixed lineage kinase domain-like antibody, MLKL antibody, mlkl antibody, Mlkl antibody
    背景
    This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
    基因ID
    197259
    UniProt
    Q9D2Y4
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