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CHEK2 抗体 (pSer516)

The 兔多克隆 anti-CHEK2 antibody (ABIN7212918) specifically detects CHEK2 in WB 和 ELISA. The antibody is reactive with 人和猴 samples.

产品编号 ABIN7212918

发货至: 中国

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Quick Overview for CHEK2 抗体 (pSer516) (ABIN7212918)

抗原

See all CHEK2 抗体

CHEK2 (Checkpoint Kinase 2 (CHEK2))

适用

人, 猴

宿主

兔

克隆类型

多克隆

标记

This CHEK2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA

Discover our top product CHEK2 Primary Antibody

抗原表位
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pSer516

原理

Chk2 (phospho Ser516) Polyclonal Antibody

特异性

Phospho-Chk2 (S516) Polyclonal Antibody detects endogenous levels of Chk2 protein only when phosphorylated at S516.

纯化方法

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

免疫原

Synthesized peptide derived from human Chk2 Phospho-Ser516

亚型

IgG
anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibody
CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibody
CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibody
CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
KD Validated CHEK2 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 24GB4585 unconjugated Recombinant Antibody

anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibody
CHEK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibody
CHEK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4B7 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 适用: 人, 猴, 犬 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 10G7 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 适用: 人, 犬 WB, IHC, IF, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 5C4 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 适用: 人, 犬 WB, IHC, IHC (p), IP, FACS 宿主: 小鼠 Monoclonal 2H5 unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

说明

Primary Antibody

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
抗原

CHEK2 (Checkpoint Kinase 2 (CHEK2))

别名

Chk2

背景

Rabbit Anti-Chk2 (phospho Ser516) Polyclonal Antibody,CHEK2, CDS1, CHK2, RAD53, Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, Cds1 homolog, Hucds1, hCds1, Checkpoint kinase 2,In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. Checkpoint kinase 2 encoded by CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Checkpoint kinase 2 interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for CHEK2.,serine threonine-protein kinase Chk2

分子量

observerd band 61kDa

基因ID

11200

UniProt

O96017

途径

p53 Pathway, Apoptosis, Cell Division Cycle