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- 抗原 See all PTPN22 抗体
- PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))
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抗原表位
- AA 1-179
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTPN22 antibody is un-conjugated
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应用范围
- ELISA, Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Tyrosine-protein phosphatase non-receptor type 22 protein (1-179AA)
- 亚型
- IgG
- Top Product
- Discover our top product PTPN22 Primary Antibody
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anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (Internal Region) antibody
Verified PTPN22 适用: 人 ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (AA 1-90) antibodyPTPN22 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (AA 1-179) antibodyPTPN22 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 4F6 unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (AA 1-233) antibodyPTPN22 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) antibodyPTPN22 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (C-Term) antibodyPTPN22 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) antibodyPTPN22 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) antibodyPTPN22 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (C-Term) antibodyPTPN22 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (AA 1-752) antibodyPTPN22 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: IF:1:200-1:500,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))
- 别名
- PTPN22 (PTPN22 产品)
- 别名
- 70zpep antibody, PEP antibody, Ptpn8 antibody, LYP antibody, LYP1 antibody, LYP2 antibody, PTPN8 antibody, protein tyrosine phosphatase, non-receptor type 22 (lymphoid) antibody, protein tyrosine phosphatase, non-receptor type 22 antibody, Ptpn22 antibody, PTPN22 antibody
- 背景
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Background: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating \'Tyr-394\' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating \'Tyr-493\' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).
Aliases: Hematopoietic cell protein tyrosine phosphatase 70Z PEP antibody, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP antibody, Lymphoid phosphatase antibody, Lymphoid specific protein tyrosine phosphatase antibody, lymphoid-specific, inducible human protein tyrosine phosphatase antibody, Lyp 1 antibody, Lyp 2 antibody, LyP antibody, Lyp1 antibody, Lyp2 antibody, LyPTP antibody, OTTHUMP00000013720 antibody, OTTHUMP00000013721 antibody, OTTHUMP00000233450 antibody, OTTHUMP00000233451 antibody, PEP antibody, PEST-domain phosphatase antibody, Protein tyrosine phosphatase non receptor type 22 (lymphoid) antibody, Protein tyrosine phosphatase non receptor type 22 antibody, Protein tyrosine phosphatase non receptor type 8 antibody, Protein tyrosine phosphatase non receptor type 8, formerly antibody, PTN22_HUMAN antibody, PTPN 22 antibody, PTPN 8 antibody, Ptpn22 antibody, PTPN8 antibody, PTPN8, formerly antibody, Tyrosine-protein phosphatase non-receptor type 22 antibody
- UniProt
- Q9Y2R2
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