PTPN22 抗体 (C-Term)
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- 抗原 See all PTPN22 抗体
- PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTPN22 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- PTPN22 Antibody detects endogenous levels of total PTPN22.
- 预测反应
- Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PTPN22, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PTPN22 Primary Antibody
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anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (Internal Region) antibody
Verified PTPN22 适用: 人 ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (AA 1-90) antibodyPTPN22 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (AA 1-179) antibodyPTPN22 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 4F6 unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (AA 1-233) antibodyPTPN22 适用: 人 WB, ELISA, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) antibodyPTPN22 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) antibodyPTPN22 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) antibodyPTPN22 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (C-Term) antibodyPTPN22 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (AA 1-752) antibodyPTPN22 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22) (AA 10-113) antibodyPTPN22 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1A6 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))
- 别名
- PTPN22 (PTPN22 产品)
- 别名
- 70zpep antibody, PEP antibody, Ptpn8 antibody, LYP antibody, LYP1 antibody, LYP2 antibody, PTPN8 antibody, protein tyrosine phosphatase, non-receptor type 22 (lymphoid) antibody, protein tyrosine phosphatase, non-receptor type 22 antibody, Ptpn22 antibody, PTPN22 antibody
- 背景
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Description: Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).
Gene: PTPN22
- 分子量
- 92kDa
- 基因ID
- 26191
- UniProt
- Q9Y2R2
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