JNK2 抗体 (AA 1-424)
Quick Overview for JNK2 抗体 (AA 1-424) (ABIN7160013)
抗原
See all JNK2 (MAPK9) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-424
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交叉反应
- 人
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纯化方法
- >95%, Protein G purified
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免疫原
- Recombinant Human Mitogen-activated protein kinase 9 protein (1-424AA)
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 321-424) antibody
MAPK9 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D6 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 321-424) antibodyMAPK9 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2F8 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibodyMAPK9 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 1C1-3A8 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibodyMAPK9 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2G3 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 227-382) antibodyMAPK9 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2F6H11 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 130-387) antibodyMAPK9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibodyMAPK9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibodyMAPK9 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 349-379), (C-Term) antibodyMAPK9 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2510 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibodyMAPK9 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Recommended dilution: IF:1:200-1:500, IP:1:200-1:2000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 -
储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))
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别名
- MAPK9
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背景
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Background: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock. MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
Aliases: c Jun kinase 2 antibody, C Jun N terminal kinase 2 antibody, c-Jun N-terminal kinase 2 antibody, JNK 55 antibody, JNK-55 antibody, JNK2 alpha antibody, JNK2 antibody, JNK2 beta antibody, JNK2A antibody, JNK2alpha antibody, JNK2B antibody, JNK2BETA antibody, Jun kinase antibody, MAP kinase 9 antibody, MAPK 9 antibody, Mapk9 antibody, Mitogen activated protein kinase 9 antibody, Mitogen-activated protein kinase 9 antibody, MK09_HUMAN antibody, P54a antibody, p54aSAPK antibody, PRKM9 antibody, Protein kinase, mitogen-activated, 9 antibody, SAPK alpha antibody, SAPK antibody, SAPK1a antibody, Stress activated protein kinase 1a antibody, Stress-activated protein kinase JNK2 antibody
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UniProt
- P45984
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途径
- MAPK Pathway, WNT signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteins
抗原
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