POLD2 抗体 (AA 245-430) (HRP)
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- 抗原 See all POLD2 抗体
- POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))
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抗原表位
- AA 245-430
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This POLD2 antibody is conjugated to HRP
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应用范围
- ELISA
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human DNA polymerase delta subunit 2 protein (245-430AA)
- 亚型
- IgG
- Top Product
- Discover our top product POLD2 Primary Antibody
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anti-Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2) antibody
POLD2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2) (AA 1-469) antibodyPOLD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2) (AA 1-469) antibodyPOLD2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2) (AA 245-430) antibodyPOLD2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2) (AA 143-192) antibodyPOLD2 适用: 人, 大鼠, 小鼠, 兔, Cow, 豚鼠, Bat, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2) (AA 120-360) antibodyPOLD2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2) (AA 232-265) antibodyPOLD2 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal RB46018 unconjugated
anti-Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2) (AA 237-265) antibodyPOLD2 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal RB46018 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- POLD2 (Polymerase (DNA Directed), delta 2, Accessory Subunit (POLD2))
- 别名
- POLD2 (POLD2 产品)
- 别名
- 50kDa antibody, p50 antibody, po1D2 antibody, cdc1 antibody, si:dz150f13.3 antibody, zgc:55633 antibody, zgc:77043 antibody, DNA polymerase delta 2, accessory subunit antibody, polymerase (DNA directed), delta 2, regulatory subunit antibody, polymerase (DNA directed), delta 2, accessory subunit L homeolog antibody, POLD2 antibody, Pold2 antibody, pold2.L antibody, pold2 antibody
- 背景
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Background: As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5\'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the POLZ complex. Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the minimal DNA polymerase zeta complex, consisting of only REV3L and REV7 (PubMed:24449906).
Aliases: DNA polymerase delta subunit 2 antibody, DNA polymerase delta subunit p50 antibody, DNA polymerase subunit delta 2 antibody, DNA polymerase subunit delta p50 antibody, DPOD2_HUMAN antibody, POLD 2 antibody, pold2 antibody
- UniProt
- P49005
- 途径
- Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
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