SMARCC1 抗体
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- 抗原 See all SMARCC1 抗体
- SMARCC1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SMARCC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人
- 纯化方法
- Affinity purified
- 免疫原
- Purified recombinant human BAF155 protein fragments expressed in E.coli.
- 亚型
- IgG1, IgG1 kappa
- Top Product
- Discover our top product SMARCC1 Primary Antibody
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- 应用备注
- Recommended dilution:WB:1:500-1:5000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified mouse monoclonal in PBS( pH 7.4) containing with 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- SMARCC1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1))
- 别名
- SMARCC1 (SMARCC1 产品)
- 别名
- smarcc1 antibody, MGC53976 antibody, BAF155 antibody, CRACC1 antibody, Rsc8 antibody, SRG3 antibody, SWI3 antibody, AI115498 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 L homeolog antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 antibody, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 antibody, smarcc1.L antibody, smarcc1a antibody, SMARCC1 antibody, Smarcc1 antibody
- 背景
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Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology).May stimulate the ATPase activity of the catalytic subunit of the complex.Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex,a chromatin-remodeling complex recruited by vitamin D receptor (VDR),which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex).During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state.The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A,are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF).The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells.The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth by similarity.
Aliases: AI115498, BAF 155, BAF155, BRG 1 associated factor 155, BRG1 associated factor 155, BRG1-associated factor 155, Chromatin remodeling complex BAF155 subunit, CRACC 1, CRACC1, Mammalian chromatin remodeling complex BRG 1 associated factor 155,
- UniProt
- Q92922
- 途径
- Chromatin Binding
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