FGFR1 抗体 (pTyr766)
Quick Overview for FGFR1 抗体 (pTyr766) (ABIN7139064)
抗原
See all FGFR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr766
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of tyrosine 766 (Q-E-Y(p)-L-D) derived from FGFR1.
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亚型
- IgG
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anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 19-48), (N-Term) antibody
FGFR1 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB04521 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 236-362) antibodyFGFR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (C-Term) antibodyFGFR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 19-48) antibodyFGFR1 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 31-150) antibodyFGFR1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 5E9 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (pTyr766) antibodyFGFR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (Tyr766) antibodyFGFR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 291-324) antibodyFGFR1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB50848 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 806-842), (C-Term) antibodyFGFR1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 1440CT772-50-23 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) antibodyFGFR1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C3 unconjugated
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应用备注
- WB:1:500-1:1000,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
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别名
- FGFR1
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背景
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Background:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
Cross MJ, et al. (2002) Mol Biol Cell 13, 2881-93. Foehr ED, Raffioni S, Murray-Rust J, Bradshaw RA (2001)J Biol Chem 276, 37529-36. Cross MJ, et al. (2000)J Cell Sci 113 ( Pt 4), 643-51 .Aliases: Basic fibroblast growth factor receptor 1 antibody, bFGF-R-1 antibody, BFGFR antibody, CD331 antibody, CEK antibody, FGFBR antibody, FGFR 1 antibody, FGFR-1 antibody, FGFR1 antibody, FGFR1/PLAG1 fusion antibody, FGFR1_HUMAN antibody, fibroblast growth factor receptor 1 antibody, FLG antibody, FLT-2 antibody, FLT2 antibody, Fms-like gene antibody, Fms-like tyrosine kinase 2 antibody, fms-related tyrosine kinase 2 antibody, HBGFR antibody, heparin-binding growth factor receptor antibody, HH2 antibody, HRTFDS antibody, hydroxyaryl-protein kinase antibody, KAL2 antibody, N-SAM antibody, OGD antibody, Proto-oncogene c-Fgr antibody
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UniProt
- P11362
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins
抗原
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