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IKK alpha 抗体 (pThr23)

Name: IKK alpha 抗体 (pThr23)
Brand: antibodies-online
SKU: ABIN7138810
Availability: OutOfStock

This anti-IKK alpha antibody is a 兔多克隆 antibody detecting IKK alpha in WB, IHC 和 ELISA. Suitable for 人.

Western blot analysis of extracts from 293 cells untreated or treated with TNF using IKK a(Phospho-Thr23) Antibody. (IKK alpha 抗体 (pThr23))

Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using IKK a(Phospho-Thr23) Antibody(left) or the same antibody preincubated with blocking peptide(right). (IKK alpha 抗体 (pThr23))

IHC

Western blot analysis of extracts from Hela cells, treated with EGF or calf intestinal phosphatase (CIP), using IKK α (Phospho-Thr23) Antibody. (IKK alpha 抗体 (pThr23))

3 images

产品编号 ABIN7138810

发货至: 中国

Datasheet as PDF

Quick Overview for IKK alpha 抗体 (pThr23) (ABIN7138810)

抗原

See all IKK alpha (CHUK) 抗体

IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

适用

人

宿主

兔

克隆类型

多克隆

标记

This IKK alpha antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Discover our top product CHUK Primary Antibody

抗原表位
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8

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3

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2

2

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1

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1
pThr23

交叉反应

人, 小鼠, 大鼠

纯化方法

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

免疫原

Peptide sequence around phosphorylation site of threonine 23 (L-G-T(p)-G-G) derived from Human IKK a.

亚型

IgG
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (C-Term) antibody
CHUK 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (pSer176), (pSer177) antibody
CHUK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 646-745) antibody
CHUK 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4B8 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 646-745) antibody
CHUK 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 1F8 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (pThr23) antibody
CHUK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody
CHUK 适用: 人 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3G12H9 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibody
CHUK 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB2159 unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (N-Term) antibody
CHUK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 551-650) antibody
CHUK 适用: 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 84-112), (N-Term) antibody
CHUK 适用: 人 WB 宿主: 兔 Polyclonal RB41290 unconjugated

应用备注

WB:1:500-1:1000, IHC:1:50-1:100,

限制

仅限研究用
状态

Liquid

缓冲液

Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C,-80 °C

储存方法

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
抗原

IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

别名

CHUK

背景

Background:
Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.

Yuan ZQ, et al.(2002) J Biol Chem, 277(33): 29973-82.
Ozes ON, et al. (1999) Nature, 401(6748): 82-5.
Aliases: chuk antibody, CHUK1 antibody, Conserved Helix Loop Helix Ubiquitous Kinase antibody, Conserved helix loop ubiquitous kinase antibody, Conserved helix-loop-helix ubiquitous kinase antibody, I Kappa B Kinase 1 antibody, I Kappa B Kinase Alpha antibody, I-kappa-B kinase 1 antibody, I-kappa-B kinase alpha antibody, IkappaB kinase antibody, IkB kinase alpha subunit antibody, IkBKA antibody, IKK 1 antibody, IKK A antibody, IKK a kinase antibody, IKK-A antibody, IKK-alpha antibody, IKK1 antibody, IKKA antibody, IKKA_HUMAN antibody, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody, Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody, Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody, NFKBIKA antibody, Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody, Nuclear factor NF kappa B inhibitor kinase alpha antibody, Nuclear factor NF-kappa-B inhibitor kinase alpha antibody, Nuclear factor NFkappaB inhibitor kinase alpha antibody, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody, TCF-16 antibody, TCF16 antibody, Transcription factor 16 antibody

UniProt

O15111

途径

PI3K-Akt Signaling, NF-kappaB Signaling, RTK signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins