IKK alpha 抗体 (pSer176, pSer177)
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北京 101111
Quick Overview for IKK alpha 抗体 (pSer176, pSer177) (ABIN7138451)
抗原
See all IKK alpha (CHUK) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer176, pSer177
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原理
- Phospho-CHUK/IKBKB (Ser176/177) Antibody
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交叉反应
- 小鼠, 大鼠
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纯化方法
- Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
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免疫原
- Peptide sequence around phosphorylation site of serine 176/177 (Q-G-S(p)-L-C) derived from Human IKK-alpha/beta.
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亚型
- IgG
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anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (C-Term) antibody
CHUK 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (pSer176), (pSer177) antibodyCHUK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 646-745) antibodyCHUK 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4B8 unconjugated
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (pThr23) antibodyCHUK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 646-745) antibodyCHUK 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 1F8 unconjugated
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibodyCHUK 适用: 人 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3G12H9 unconjugated
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 411-745) antibodyCHUK 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (pThr23) antibodyCHUK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) antibodyCHUK 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB2159 unconjugated
anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (N-Term) antibodyCHUK 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))
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别名
- CHUK
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背景
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Background:
Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3.
Chandrakesan P, et al. (2010)J Biol Chem 285, 33485-98
Hinz M, et al. (2010Mol Cell 40, 63-74
Choudhary S, Lu M, Cui R, Brasier AR (2007)Mol Endocrinol 21, 2203-17Aliases: chuk antibody, CHUK1 antibody, Conserved Helix Loop Helix Ubiquitous Kinase antibody, Conserved helix loop ubiquitous kinase antibody, Conserved helix-loop-helix ubiquitous kinase antibody, I Kappa B Kinase 1 antibody, I Kappa B Kinase Alpha antibody, I-kappa-B kinase 1 antibody, I-kappa-B kinase alpha antibody, IkappaB kinase antibody, IkB kinase alpha subunit antibody, IkBKA antibody, IKK 1 antibody, IKK A antibody, IKK a kinase antibody, IKK-A antibody, IKK-alpha antibody, IKK1 antibody, IKKA antibody, IKKA_HUMAN antibody, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells antibody, Inhibitor Of Nuclear Factor Kappa B Kinase Alpha Subunit antibody, Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody, NFKBIKA antibody, Nuclear Factor Kappa B Inhibitor Kinase Alpha antibody, Nuclear factor NF kappa B inhibitor kinase alpha antibody, Nuclear factor NF-kappa-B inhibitor kinase alpha antibody, Nuclear factor NFkappaB inhibitor kinase alpha antibody, Nuclear Factor Of Kappa Light Chain Gene Enhancer In B Cells Inhibitor antibody, TCF-16 antibody, TCF16 antibody, Transcription factor 16 antibody
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UniProt
- O15111
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途径
- PI3K-Akt Signaling, NF-kappaB Signaling, RTK signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
抗原
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