ERCC6L 抗体
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- 抗原 See all ERCC6L 抗体
- ERCC6L (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like (ERCC6L))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ERCC6L antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC)
- 交叉反应
- 人
- 纯化方法
- Antigen affinity purification
- 免疫原
- Fusion protein of Human ERCC6L
- 亚型
- IgG
- Top Product
- Discover our top product ERCC6L Primary Antibody
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- 应用备注
- ELISA:1:2000-1:5000, IHC:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- -20 °C, pH 7.4 PBS, 0.05 % Sodium azide, 40 % Glycerol
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- ERCC6L (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6-Like (ERCC6L))
- 别名
- ERCC6L (ERCC6L 产品)
- 别名
- PICH antibody, RAD26L antibody, BC004701 antibody, D330021P09Rik antibody, RGD1565734 antibody, fc22h03 antibody, si:ch211-278b8.3 antibody, wu:fc22h03 antibody, ERCC excision repair 6 like, spindle assembly checkpoint helicase antibody, excision repair cross-complementing rodent repair deficiency complementation group 6 like antibody, DNA excision repair protein ERCC-6-like antibody, excision repair cross-complementation group 6-like antibody, ERCC6L antibody, Ercc6l antibody, LOC100373376 antibody, LOC100494766 antibody, LOC100552957 antibody, LOC100560751 antibody, LOC100563247 antibody, ercc6l antibody
- 背景
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Background: PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1,250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain.
Aliases: ATP dependent helicase ERCC6 like antibody, ATP-dependent helicase ERCC6-like antibody, DNA excision repair protein ERCC 6 like antibody, DNA excision repair protein ERCC-6-like antibody, ERC6L_HUMAN antibody, ERCC 6L antibody, Ercc6l antibody, Excision repair cross complementing rodent repair deficiency complementation group 6 like antibody, Excision repair protein ERCC6 like antibody, FLJ20105 antibody, MGC131695 antibody, PICH antibody, Plk1 interacting checkpoint helicase antibody, PLK1-interacting checkpoint helicase antibody, SNF2/RAD54 family protein antibody, Tumor antigen BJ HCC 15 antibody, Tumor antigen BJ-HCC-15 antibody
- UniProt
- Q2NKX8
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