Recombinant ATF2 抗体
Quick Overview for Recombinant ATF2 抗体 (ABIN7127346)
抗原
See all ATF2 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人
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纯化方法
- Affinity-chromatography
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免疫原
- A synthesized peptide derived from human ATF2
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亚型
- IgG
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anti-Activating Transcription Factor 2 (ATF2) (AA 1-190) antibody
ATF2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (pThr51), (pThr69) antibodyATF2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (pThr53), (pThr71) antibodyATF2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (pSer44), (pSer62) antibodyATF2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (AA 93-450) antibodyATF2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (C-Term) antibodyATF2 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (AA 93-450) antibodyATF2 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (pThr73) antibodyATF2 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) antibodyATF2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C12 unconjugated
anti-Activating Transcription Factor 2 (ATF2) (AA 1-209) antibodyATF2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E12 unconjugated
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应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200,
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C,-80 °C
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储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- ATF2 (Activating Transcription Factor 2 (ATF2))
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别名
- ATF2
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背景
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Background: Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
Aliases: Cyclic AMP-dependent transcription factor ATF-2, Activating transcription factor 2, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, HB16, Histone acetyltransferase ATF2, cAMP response element-binding protein CRE-BP1, ATF2, CREB2, CREBP1
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UniProt
- P15336
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途径
- MAPK Pathway, RTK signaling, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades
抗原
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