Recombinant ACVR2B 抗体
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- 抗原 See all ACVR2B 抗体
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- 抗体类型
- Recombinant Antibody
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This ACVR2B antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), ELISA
- 交叉反应
- 人
- 纯化方法
- Affinity-chromatography
- 免疫原
- A synthesized peptide derived from human Activin Receptor Type IIB
- 克隆位点
- 7B10
- 亚型
- IgG
- Top Product
- Discover our top product ACVR2B Primary Antibody
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anti-Activin A Receptor, Type IIB (ACVR2B) (Middle Region) antibody
ACVR2B 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 绵羊, 豚鼠, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Activin A Receptor, Type IIB (ACVR2B) (AA 45-150) antibodyACVR2B 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Activin A Receptor, Type IIB (ACVR2B) (AA 21-120) antibodyACVR2B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C11 unconjugated
anti-Activin A Receptor, Type IIB (ACVR2B) (N-Term) antibodyACVR2B 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Activin A Receptor, Type IIB (ACVR2B) (AA 21-120) antibodyACVR2B 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Activin A Receptor, Type IIB (ACVR2B) (Internal Region) antibodyACVR2B 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Activin A Receptor, Type IIB (ACVR2B) (AA 50-150) antibodyACVR2B 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Activin A Receptor, Type IIB (ACVR2B) (Extracellular Domain) antibodyACVR2B 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Activin A Receptor, Type IIB (ACVR2B) (AA 214-350) antibodyACVR2B 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activin A Receptor, Type IIB (ACVR2B) (AA 1-30) antibodyACVR2B 适用: 人 WB 宿主: 兔 Polyclonal RB08166 unconjugated
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- 应用备注
- Recommended dilution: IHC:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- 别名
- ACVR2B (ACVR2B 产品)
- 别名
- ACVR2B antibody, XAR1 antibody, actr-iib antibody, actriib antibody, ACTRIIB antibody, ActR-IIB antibody, HTX4 antibody, ActRIIB antibody, actr2b antibody, actrIIb antibody, wu:fj97d11 antibody, activin A receptor type 2B antibody, activin A receptor type 2B L homeolog antibody, activin A receptor type 2Ba antibody, activin receptor IIB antibody, ACVR2B antibody, acvr2b antibody, acvr2b.L antibody, Acvr2b antibody, acvr2ba antibody
- 背景
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Background: Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.
Aliases: Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB), ACVR2B
- UniProt
- Q13705
- 途径
- Hormone Transport, Cancer Immune Checkpoints
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