SET/TAF-I 抗体
Quick Overview for SET/TAF-I 抗体 (ABIN7126932)
抗原
See all SET/TAF-I (SET) 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Protein phosphatase 2A (PP2A) is a major mammalian protein serine/threonine phosphatase that regulates diverse cellular processes. Inhibitor 1 of PP2A (I1PP2A) and inhibitor 2 of PP2A (I2PP2A), which share large sequence similarity, are heat-stable protein inhibitors of the cellular phosphatase activity of PP2A. I1PP2A and I2PP2A were initially characterized as putative HLA class II associated proteins Phap I and Phap II. These inhibitor proteins act noncompetitively to selectively inhibit PP2A, but do not affect the phosphatase activity of the related proteins PP1, PP2B and PP2C. The I1PP2A protein is localized to both the cytoplasm and the nucleus. In contrast, I2PP2A is located predominantly in the nucleus and is highly expressed in Wilms tumor cells. Transient expression of I2PP2A in HEK-293 cells leads to an increase in the DNA binding activity of the proto-oncogene c-Jun.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human SET protein
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亚型
- IgG1
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anti-SET Nuclear Oncogene (SET) (N-Term) antibody
Verified SET 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 1-277) antibodySET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 146-277) antibodySET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人, 小鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 1-277) antibodySET 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal M1-F5 unconjugated
anti-SET Nuclear Oncogene (SET) (N-Term) antibodySET 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人, 小鼠, 大鼠 WB, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 147-235) antibodySET 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 35-84) antibodySET 适用: 人, 小鼠, 大鼠, 小鸡, 非洲爪蟾, 斑马鱼, Cow, 马, 兔, 豚鼠, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), ,Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or HepG2 cells.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- SET/TAF-I (SET) (SET Nuclear Oncogene (SET))
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别名
- SET
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背景
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2PP2A, HLA DR associated protein II, IGAAD, Inhibitor of granzyme A activated DNase, inhibitor-2 of protein phosphatase-2A, IPP2A2, PHAPII, Phosphatase 2A inhibitor I2PP2A, protein phosphatase type 2A inhibitor, TAFI, Template-Activating Factor-I, chromatin remodelling factor, SET nuclear oncogene, SET translocation (myeloid leukemia-associated),SET
Cellular localisation: Cytoplasm > cytosol. Endoplasmic reticulum. Nucleus > nucleoplasm. -
分子量
- 39kDa
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基因ID
- 6418, 436687
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UniProt
- Q01105
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途径
- Apoptosis
抗原
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