HLAG 抗体
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北京 101111
Quick Overview for HLAG 抗体 (ABIN7126512)
抗原
See all HLAG 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- HLA-G (Major Histocompatibility Complex, class I, G) Antibody
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特异性
- Major histocompatibility complex (MHC), human leukocyte antigen (HLA) molecules are cell-surface receptors that bind foreign peptides and present them to T lymphocytes. MHC class I molecules consist of two polypeptide chains, an a or heavy chain, and a non-covalently associated protein, æ2-microglobulin. Cytotoxic T lymphocytes bind antigenic peptides presented by MHC class I molecules. Antigens that bind to MHC class I molecules are typically 8-10 residues in length and are stabilized in a peptide binding groove. MHC class II molecules are encoded by polymorphic MHC genes and consist of a noncovalent complex of an a and b chain. Helper T lymphocytes bind antigenic peptides presented by MHC class II molecules. MHC class II molecules bind 13-18 amino acid antigenic peptides. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM and -DO molecules regulate binding of exogenous peptides to class II molecules (HLA-DR) by sustaining a conformation that favors peptide exchange. The differential structural properties of MHC class I and class II molecules account for their respective roles in activating different populations of T lymphocytes.
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交叉反应 （详细）
- Human.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.
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免疫原
- Purified His-tagged HLA-G protein.
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亚型
- IgG1, kappa
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anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody
HLAG 适用: 人 WB, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal MEM-G-1 unconjugated
anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (PE)HLAG 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-G-9 PE
anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibodyHLAG 适用: 人 ELISA, FACS, IP, IHC (fro), ICC 宿主: 小鼠 Monoclonal MEM-G-9 unconjugated
anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) (C-Term) antibody (PE)HLAG 适用: 人 ICFC 宿主: 小鼠 Monoclonal 5A6G7 PE
anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (FITC)HLAG 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-G-9 FITC
anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (Biotin)HLAG 适用: 人 ELISA, FACS, IP, IHC (fro), ICC 宿主: 小鼠 Monoclonal MEM-G-9 Biotin
anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibodyHLAG 适用: 人 ELISA, FACS, IP, IHC (fro), ICC 宿主: 小鼠 Monoclonal MEM-G-9 unconjugated
anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) antibody (APC)HLAG 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-G-9 APC
anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) (AA 62-89) antibodyHLAG 适用: 人 WB, ELISA, FACS, IHC 宿主: 兔 Polyclonal unconjugated
anti-HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG) (C-Term) antibody (Biotin)HLAG 适用: 人 WB, ELISA, FACS, IHC (fro), IHC (p), ICC 宿主: 小鼠 Monoclonal 5A6G7 Biotin
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应用备注
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Known_Application: Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95 °C followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
Positive_Control: Raji cells. Expressed in trophoblasts.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- HLAG (HLA Class I Histocompatibility Antigen, alpha Chain G (HLAG))
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别名
- HLA-G
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背景
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B2 microglobulin, DADB-15K14.8, HLA 6.0, HLA G histocompatibility antigen class I G, HLA G3, HLA60, HLAG, Major histocompatibility complex class I G, MHC class I antigen G, MHC G, T-cell A locus, TCA
JEG-3, Raji cells. Expressed in trophoblasts.
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分子量
- 39kDa
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基因ID
- 3135, 512152
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UniProt
- P17693
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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