RPA3 抗体
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- 抗原 See all RPA3 抗体
- RPA3 (Replication Protein A3, 14kDa (RPA3))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RPA3 antibody is un-conjugated
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应用范围
- ELISA
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- replication protein A3, 14kDa
- 亚型
- IgG
- Top Product
- Discover our top product RPA3 Primary Antibody
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anti-Replication Protein A3, 14kDa (RPA3) (AA 12-121) antibody
RPA3 适用: 人 ELISA, WB, IHC (p), RNAi 宿主: 小鼠 Monoclonal 1F4 unconjugated
anti-Replication Protein A3, 14kDa (RPA3) antibodyRPA3 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A3, 14kDa (RPA3) (AA 1-121) antibodyRPA3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Replication Protein A3, 14kDa (RPA3) (AA 6-121) antibodyRPA3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A3, 14kDa (RPA3) antibodyRPA3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A3, 14kDa (RPA3) (AA 1-119) antibodyRPA3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Replication Protein A3, 14kDa (RPA3) (AA 1-119) antibodyRPA3 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- RPA3 (Replication Protein A3, 14kDa (RPA3))
- 别名
- RPA3 (RPA3 产品)
- 别名
- REPA3 antibody, 14kDa antibody, C330026P08Rik antibody, im:6908405 antibody, zgc:56310 antibody, zgc:86697 antibody, rpa3 antibody, MGC82610 antibody, RPA3 antibody, repa3 antibody, replication protein A3 antibody, replication protein A3 S homeolog antibody, replication protein A3 L homeolog antibody, RPA3 antibody, Rpa3 antibody, rpa3 antibody, rpa3.S antibody, rpa3.L antibody
- 背景
- Synonyms:REPA3, RPA14 Background:As part of the heterotrimeric replication protein A complex(RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage(PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response(PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin, in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair(PubMed:7697716). Plays also a role in base excision repair(BER), probably through interaction with UNG(PubMed:9765279). Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. RPA3 has its own single-stranded DNA-binding activity and may be responsible for polarity of the binding of the complex to DNA(PubMed:19010961). As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase. The aRPA may not promote efficient priming by DNA polymerase alpha but could support DNA synthesis by polymerase delta in presence of PCNA and replication factor C(RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange(PubMed:19996105).
- 基因ID
- 6119
- UniProt
- P35244
- 途径
- Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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