Lamin A/C 抗体 (AA 1-100)
Quick Overview for Lamin A/C 抗体 (AA 1-100) (ABIN7091321)
抗原
See all Lamin A/C (LMNA) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-100
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交叉反应
- 人, 大鼠
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预测反应
- Mouse,Dog,Cow,Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant human lamin A
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亚型
- IgG
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应用备注
- WB 1:300-5000
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- Lamin A/C (LMNA)
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别名
- Lamin A/C
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背景
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Synonyms: Lamin A + Lamin C, Lamin A + C, LMN1, 70 kDa lamin, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LAMIN A, lamin A/C, LAMIN C, LDP1, LFP, LGMD1B, LMN 1, LMN A, LMN C, LMNA, LMNC, NY REN 32 antigen, PRO1, LMNA_HUMAN, Prelamin-A/C, Renal carcinoma antigen NY-REN-32.
Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
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基因ID
- 4000
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UniProt
- P02545
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途径
- Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
抗原
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