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Lamin A/C 抗体 (AA 1-100)

The 小鼠 单克隆 anti-Lamin A/C antibody (Clone 3E1) (ABIN7091321) specifically detects Lamin A/C in WB. The antibody is reactive with 人 和 大鼠 samples.
产品编号 ABIN7091321
发货至: 中国
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Quick Overview for Lamin A/C 抗体 (AA 1-100) (ABIN7091321)

抗原

See all Lamin A/C (LMNA) 抗体
Lamin A/C (LMNA)

适用

  • 174
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  • 1
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人, 大鼠

宿主

  • 145
  • 42
  • 2
  • 1
小鼠

克隆类型

  • 106
  • 84
单克隆

标记

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This Lamin A/C antibody is un-conjugated

应用范围

  • 160
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  • 13
  • 7
  • 3
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Western Blotting (WB)

克隆位点

3E1
  • 抗原表位

    • 11
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    AA 1-100

    交叉反应

    人, 大鼠

    预测反应

    Mouse,Dog,Cow,Pig,Horse

    纯化方法

    Purified by Protein A.

    免疫原

    Recombinant human lamin A

    亚型

    IgG
  • 应用备注

    WB 1:300-5000

    限制

    仅限研究用
  • 浓度

    1 μg/μL

    缓冲液

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    Lamin A/C (LMNA)

    别名

    Lamin A/C

    背景

    Synonyms: Lamin A + Lamin C, Lamin A + C, LMN1, 70 kDa lamin, CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LAMIN A, lamin A/C, LAMIN C, LDP1, LFP, LGMD1B, LMN 1, LMN A, LMN C, LMNA, LMNC, NY REN 32 antigen, PRO1, LMNA_HUMAN, Prelamin-A/C, Renal carcinoma antigen NY-REN-32.

    Background: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

    基因ID

    4000

    UniProt

    P02545

    途径

    Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
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