TREX1 抗体
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- 抗原 See all TREX1 抗体
- TREX1 (three Prime Repair Exonuclease 1 (TREX1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This TREX1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- 交叉反应
- 人
- 纯化方法
- Purified by Protein A.
- 免疫原
- Recombinant protein within human TREX1 aa 100-300.
- 克隆位点
- 6C2
- 亚型
- IgG
- Top Product
- Discover our top product TREX1 Primary Antibody
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anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-369) antibody
TREX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-270) antibodyTREX1 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-270) antibodyTREX1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-304) antibodyTREX1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-100) antibodyTREX1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F10 unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 6-369) antibodyTREX1 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-304) antibodyTREX1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-369) antibodyTREX1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) (AA 1-100) antibodyTREX1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B1 unconjugated
anti-three Prime Repair Exonuclease 1 (TREX1) antibodyTREX1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- TREX1 (three Prime Repair Exonuclease 1 (TREX1))
- 别名
- TREX1 (TREX1 产品)
- 别名
- AGS1 antibody, CRV antibody, DRN3 antibody, HERNS antibody, 1661 antibody, AU041952 antibody, RGD1309596 antibody, three prime repair exonuclease 1 antibody, CpipJ_CPIJ012074 antibody, Tsp_03749 antibody, TREX1 antibody, Trex1 antibody
- 背景
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Synonyms: Three-prime repair exonuclease 1, 3'-5' exonuclease TREX1, Deoxyribonuclease III, DNase III, TREX1
Background: Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.
- 基因ID
- 11277
- UniProt
- Q9NSU2
- 途径
- Apoptosis
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