我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

SET/TAF-I 抗体

Name: SET/TAF-I 抗体
SKU: ABIN6944862
Availability: OutOfStock

This anti-SET/TAF-I antibody is a 兔单克隆 antibody detecting SET/TAF-I in WB, IHC (p), IF (cc) 和 IF (p). Suitable for 人, 小鼠和大鼠.

产品编号 ABIN6944862

发货至: 中国

Datasheet as PDF

Quick Overview for SET/TAF-I 抗体 (ABIN6944862)

抗原

See all SET/TAF-I (SET) 抗体

SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

单克隆

标记

This SET/TAF-I antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

克隆位点

2A1

Discover our top product SET Primary Antibody

交叉反应

人, 小鼠, 大鼠

纯化方法

Purified by Protein A.

免疫原

Synthetic peptide within Human SET aa 200 to the C-terminus

亚型

IgG
anti-SET Nuclear Oncogene (SET) (N-Term) antibody
Verified SET 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 1-277) antibody
SET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) antibody
SET 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 146-277) antibody
SET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) antibody
SET 适用: 人, 小鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 1-277) antibody
SET 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal M1-F5 unconjugated

anti-SET Nuclear Oncogene (SET) (N-Term) antibody
SET 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) antibody
SET 适用: 人, 小鼠, 大鼠 WB, FACS, ICC 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 147-235) antibody
SET 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 35-84) antibody
SET 适用: 人, 小鼠, 大鼠, 小鸡, 非洲爪蟾, 斑马鱼, Cow, 马, 兔, 豚鼠, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

有效期

12 months
抗原

SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

别名

SET

背景

Synonyms: Protein SET, HLA-DR-associated protein II, Inhibitor of granzyme A-activated DNase, PHAPII, Phosphatase 2A inhibitor I2PP2A, Template-activating factor I, IGAAD, I-2PP2A, TAF-I.
Background: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins, however, isoform 2 specific activity is higher.

基因ID

6418

UniProt

Q01105

途径

Apoptosis