Recombinant SET/TAF-I 抗体 (C-Term)
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北京 101111
Quick Overview for Recombinant SET/TAF-I 抗体 (C-Term) (ABIN6944862)
抗原
See all SET/TAF-I (SET) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- SET Recombinant Antibody
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交叉反应
- 人
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预测反应
- Mouse,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- Synthetic peptide within Human SET aa 200 to the C-terminus
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亚型
- IgG
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anti-SET Nuclear Oncogene (SET) (N-Term) antibody
Verified SET 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 125-175) antibodySET 适用: 人, 小鼠 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 1-277) antibodySET 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal M1-F5 unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 24GB1530 unconjugated Recombinant Antibody
anti-SET Nuclear Oncogene (SET) (N-Term) antibodySET 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 125-175) antibodySET 适用: 人 IHC 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) antibodySET 适用: 人 WB, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-SET Nuclear Oncogene (SET) (AA 35-84) antibodySET 适用: 人, 小鼠, 大鼠, 小鸡, 非洲爪蟾, 斑马鱼, Cow, 马, 豚鼠, 兔, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB(1:500-2000), IHC-P(1:100-200), IHC-F(1:100-200), IF(1:100-200), Flow-Cyt(1:50-100), ICC/IF(1:50-200)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 12 months
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- SET/TAF-I (SET) (SET Nuclear Oncogene (SET))
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别名
- SET
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背景
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Synonyms: Protein SET, HLA-DR-associated protein II, Inhibitor of granzyme A-activated DNase, PHAPII, Phosphatase 2A inhibitor I2PP2A, Template-activating factor I, IGAAD, I-2PP2A, TAF-I.
Background: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins, however, isoform 2 specific activity is higher.
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基因ID
- 6418
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UniProt
- Q01105
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途径
- Apoptosis
抗原
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