KAT2B 抗体
Quick Overview for KAT2B 抗体 (ABIN6943859)
抗原
See all KAT2B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
 - 人, 小鼠, 大鼠
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纯化方法
 - Purified by Protein A.
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免疫原
 - Recombinant protein within human PCAF aa 100-300
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亚型
 - IgG
 
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应用备注
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                        WB 1:300-5000
FCM 1:20-100
IF(ICC) 1:50-200 - 
                                            
限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 μg/μL
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缓冲液
 - Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
 - ProClin
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注意事项
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
 - 4 °C,-20 °C
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储存方法
 - Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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有效期
 - 12 months
 
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- KAT2B (K(lysine) Acetyltransferase 2B (KAT2B))
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别名
 - KAT2B
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背景
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Synonyms: Histone acetyltransferase KAT2B, Histone acetyltransferase PCAF, Lysine acetyltransferase 2B, P300/CBP-associated factor, Histone acetylase PCAF, P/CAF, KAT2B, PCAF.
Background: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4 and TBX5. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5. Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4. Also acetylates spermidine.
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基因ID
 - 8850
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UniProt
 - Q92831
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途径
 - p53 Pathway, Regulation of Carbohydrate Metabolic Process
 
抗原
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