CHEK2 抗体 (AA 1-200)
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北京 101111
Quick Overview for CHEK2 抗体 (AA 1-200) (ABIN6942554)
抗原
See all CHEK2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200
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原理
- Chk2 (7A4) Monoclonal Antibody
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- Human Chk2 between 1-200 amino acids
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亚型
- IgG
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anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibody
CHEK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4B7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 111-141), (N-Term) antibodyCHEK2 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB19067 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyKD Validated CHEK2 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 24GB4585 unconjugated Recombinant Antibody
anti-Checkpoint Kinase 2 (CHEK2) antibodyKD Validated CHEK2 适用: 人 WB, IF (p), FACS 宿主: 兔 Monoclonal 23GB3460 unconjugated Recombinant Antibody
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 适用: 人, 犬 WB, IHC, IF, FACS, IHC (p), IP 宿主: 小鼠 Monoclonal 5C4 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 适用: 人, 猴, 犬 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 10G7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 适用: 人, 犬 WB, IHC, FACS, IHC (p), IP 宿主: 小鼠 Monoclonal 2H5 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-220) antibodyCHEK2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- WB(1:300-5000), IHC-P(1:20-100), IF(ICC)(1:200-400), IHC(1:50-200)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- CHEK2 (Checkpoint Kinase 2 (CHEK2))
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别名
- Chk2
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背景
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Synonyms: Serine/threonine-protein kinase Chk2, CHK2 checkpoint homolog, Cds1 homolog, Checkpoint kinase 2, Hucds1, hCds1, CHEK2
Background: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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基因ID
- 11200
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UniProt
- O96017
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途径
- p53 Pathway, Apoptosis, Cell Division Cycle
抗原
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