TRAF1 抗体 (AA 73-219)
Quick Overview for TRAF1 抗体 (AA 73-219) (ABIN6938672)
抗原
See all TRAF1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 73-219
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特异性
- This MAb recognizes a protein of 52 kDa, which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30 % of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously, whereas those of cALCL persist and may progress and spread. Moreover, LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach, in contrast to patients with cALCL. Besides, LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR)-associated factor 1), a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84 %) show a strong TRAF1 expression, tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7 %). Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment of human TRAF1 protein (around aa 73-219) (exact sequence is proprietary)
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亚型
- IgG1 kappa
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anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 301-416) antibody
TRAF1 适用: 人, 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (C-Term) antibodyVerified TRAF1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1A6 unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 73-219) antibodyTRAF1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal TRAF1-2770 unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 131-381) antibodyTRAF1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 1-416) antibodyTRAF1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2G9-G10 unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (AA 73-219) antibodyTRAF1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal TRAF1-3298 unconjugated
anti-TNF Receptor-Associated Factor 1 (TRAF1) (C-Term) antibodyTRAF1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HeLa or 293T cells. Hodgkin s Lymphoma (IHC).
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- TRAF1 (TNF Receptor-Associated Factor 1 (TRAF1))
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别名
- TRAF1
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背景
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EBI6, EBV induced protein 6, Epstein-Barr virus-induced protein 6, TNF receptor-associated factor 1, TRAF1,TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker)
Cellular localisation: Cytoplasmic -
分子量
- 52kDa
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基因ID
- 7185, 531251
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UniProt
- Q13077
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途径
- NF-kappaB Signaling, Apoptosis, Cell-Cell Junction Organization, Asymmetric Protein Localization
抗原
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