RAD51 抗体 (AA 1-134)
Quick Overview for RAD51 抗体 (AA 1-134) (ABIN6938306)
抗原
See all RAD51 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-134
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特异性
- RAD51 is one of the key factors of DNA repair by homologous recombination and has been shown to have anti-apoptotic activity in tumor cells. RAD51 protein interacts with a variety of tumor suppressor proteins including p53, BRCA1 and BRCA2. Elevated expression of RAD51 enhances radio-resistance of human tumor cells. Overexpression of RAD51 protein in tumor cells renders them resistant against cytotoxic drugs like Cisplatin. RAD51 interacts with BRCA1 and BRCA2 to influence subcellular localization and cellular response to DNA damage. BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis from deregulation of RAD51. High-level expression of RAD51 has been observed in a variety of human malignancies.RAD51 overexpression correlates with histological grading of the tumor in invasive ductal mammary carcinoma.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment of human RAD51 protein (around aa 1-134) (exact sequence is proprietary)
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亚型
- IgG2b kappa
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anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-339) antibody
RAD51 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (Center) antibodyRAD51 适用: 人, 小鼠 WB, IP, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 81-180) antibodyRAD51 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-228) antibodyRAD51 适用: 人 WB, ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-339) antibodyRAD51 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-242) antibodyRAD51 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E5-E5 unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-134) antibodyRAD51 适用: 人 IHC, FACS, ISt, StM 宿主: 小鼠 Monoclonal RAD51-2702 unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-134) antibodyRAD51 适用: 人 WB, IHC, FACS, ISt, StM 宿主: 小鼠 Monoclonal RAD51-2701 unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) (AA 1-242) antibodyRAD51 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 4C11-B4 unconjugated
anti-DNA Repair Protein Homolog 1 (RAD51) antibodyRAD51 适用: 人, 小鼠 WB, ELISA, IP, IF 宿主: 小鸡 Polyclonal unconjugated
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应用备注
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Known_Application: Flow Cytometry (1-2 μg/mL), Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: K562, HeLa or MCF-7 cells. Colon or breast Carcinoma.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- RAD51 (DNA Repair Protein Homolog 1 (RAD51))
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别名
- RAD51
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背景
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RCA1/BRCA2 containing complex, subunit 5, BRCC5, DNA repair protein RAD51, FANCR, HsT16930, MRMV2, RAD51, RAD51 recombinase, RAD51A, RECA, RecA like protein, Recombination protein A,RAD51 (Prognostic and Response to Chemotherapy Marker)
Cellular localisation: Nuclear -
分子量
- 37kDa
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基因ID
- 5888, 631709
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UniProt
- Q06609
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途径
- DNA Damage Repair
抗原
-
