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GAD65 抗体 (AA 6-99)

GAD2 适用: 人 IHC, IHC (f) 宿主: 小鼠 Monoclonal GAD2-1960 unconjugated
产品编号 ABIN6937293
发货至: 中国
  • 抗原 See all GAD65 (GAD2) 抗体
    GAD65 (GAD2) (Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))
    抗原表位
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    AA 6-99
    适用
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    宿主
    • 91
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    小鼠
    克隆类型
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    单克隆
    标记
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    This GAD65 antibody is un-conjugated
    应用范围
    • 99
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    Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    特异性
    This MAb recognizes a protein of 65 kDa, which is identified as glutamic acid decarboxylase 2 (GDA2). It is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. There are two forms of glutamic acid decarboxylases (GAD s) that are found in the brain: GAD2 (also known as GAD65) and GAD1 (also known as GAD67). GAD1 and GAD2 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (-aminobutyric acid) from L-glutamic acid. Although both GAD s are found in the brain, GAD2 localizes to synaptic vesicle membranes in nerve terminals, while GAD1 is distributed throughout the cell. A pathogenic role for GAD2 is identified in the human pancreas since it has been identified as an autoantibody and an auto-reactive T cell target in insulin-dependent diabetes.
    交叉反应 (详细)
    Human.
    纯化方法
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    免疫原
    Recombinant human GAD2 (GAD65) protein fragment (around aa 6-99) (exact sequence is proprietary)
    克隆位点
    GAD2-1960
    亚型
    IgG2b kappa
    Top Product
    Discover our top product GAD2 Primary Antibody
  • 应用备注

    Known_Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: Pancreas or Brain (IHC).

    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    储存液
    Azide free
    储存条件
    -20 °C,-80 °C
    储存方法
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    有效期
    24 months
  • 抗原
    GAD65 (GAD2) (Glutamate Decarboxylase 2 (Pancreatic Islets and Brain, 65kDa) (GAD2))
    别名
    GAD2 (GAD2 产品)
    别名
    GAD65 antibody, gad65 antibody, F12P19.12 antibody, F12P19_12 antibody, GLUTAMATE DECARBOXYLASE 2 antibody, glutamate decarboxylase 2 antibody, zgc:112198 antibody, 6330404F12Rik antibody, GAD(65) antibody, Gad-2 antibody, glutamate decarboxylase 2 antibody, glutamate decarboxylase 1 antibody, glutamic acid decarboxylase 2 antibody, GAD2 antibody, PTRG_06148 antibody, LOC9324534 antibody, Gad2 antibody, GAD1 antibody, gad2 antibody
    背景
    DCE2, GAD2, Glutamic Acid Decarboxylase 2 (Pancreas), Glutamic Acid Decarboxylase 2 (Pancreatic Islets and Brain 65 kDa), Glutamic Acid Decarboxylase 65 (GAD65),GAD2 / GAD65 (GABAergic Neuronal Marker)
    Cellular localisation: Cytoplasmic
    分子量
    65kDa
    基因ID
    2572, 231829
    UniProt
    Q05329
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