GRB2 抗体 (Cy3)
Quick Overview for GRB2 抗体 (Cy3) (ABIN686935)
抗原
See all GRB2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Excitation / Emission Wavelengths: 550nm/570nm
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交叉反应
- 大鼠, 小鸡, 犬
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纯化方法
- purified by Protein A
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免疫原
- KLH conjugated synthetic peptide derived from human GRB2
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亚型
- IgG
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anti-Growth Factor Receptor-Bound Protein 2 (GRB2) antibody
GRB2 适用: 人, 小鼠, 大鼠, 犬, 小鸡 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (C-Term) antibodyVerified GRB2 适用: 人, 小鼠, 大鼠, Pig WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) antibodyGRB2 适用: 人 WB, IHC, IP, IF 宿主: 兔 Monoclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (C-Term) antibodyKO Validated GRB2 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 89-118) antibodyGRB2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 156-217) antibodyGRB2 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) antibodyGRB2 适用: 人, 小鼠, 大鼠, Cow, Hamster WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (N-Term) antibodyGRB2 适用: 人, 小鼠, 大鼠, 犬, Cow, 斑马鱼, 豚鼠, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) antibodyGRB2 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 6E1 unconjugated Recombinant Antibody
anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (AA 1-217) antibodyGRB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4C6-H6 unconjugated
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应用备注
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IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator. -
说明
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Excitation / Emission wavelength: 510.550nm / 570.615nm
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 µg/µL
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缓冲液
- Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store at 4 °C for 12 months
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有效期
- 12 months
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- GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
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别名
- GRB2/ASH
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背景
- Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDa protein that contains a central Src homology (SH2) domain flanked by two SH3 domains. GRB2 is believed to be a regulatory subunit of signaling molecules whose activity is modulated by receptor binding. GRB2 associates with activated (tyrosine phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3 domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of activated EGFR requires the interaction of GRB2 with the GTP binding protein dynamin, a factor essential to the formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative splicing. On SDS PAGE, GRB2 has an apparent molecular weight of 28 kDa.
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分子量
- 25kDa
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基因ID
- 2885
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途径
- RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation
抗原
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