DIABLO 抗体 (AA 131-239)
(1 reference)Quick Overview for DIABLO 抗体 (AA 131-239) (ABIN674619)
抗原
See all DIABLO 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 131-239
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Pig,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human Smac
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亚型
- IgG
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anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 211-239), (C-Term) antibody
DIABLO 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB20755 unconjugated
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 1-232) antibodyDIABLO 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 56-239) antibodyDIABLO 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 168-236) antibodyDIABLO 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 1-239) antibodyDIABLO 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (C-Term) antibodyDIABLO 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 225-239) antibodyDIABLO 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 199-212) antibodyDIABLO 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (C-Term) antibodyDIABLO 适用: 人, Cow, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Second Mitochondria-Derived Activator of Caspase (DIABLO) (AA 119-218) antibodyDIABLO 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F9 unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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: "Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts." in: International journal of molecular medicine, Vol. 32, Issue 3, pp. 615-22, (2013) (PubMed).
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: "Smac/DIABLO regulates the apoptosis of hypertrophic scar fibroblasts." in: International journal of molecular medicine, Vol. 32, Issue 3, pp. 615-22, (2013) (PubMed).
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- DIABLO (Second Mitochondria-Derived Activator of Caspase (DIABLO))
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别名
- Smac/DIABLO
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背景
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Synonyms: SMAC, DFNA64, Diablo homolog, mitochondrial, Direct IAP-binding protein with low pI, Second mitochondria-derived activator of caspase, DIABLO
Background: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
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基因ID
- 56616
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UniProt
- Q9NR28
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途径
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
抗原
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