SQSTM1 抗体 (pSer272, pThr269)
Quick Overview for SQSTM1 抗体 (pSer272, pThr269) (ABIN6655165)
抗原
See all SQSTM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer272, pThr269
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Supplier Product No.
- 600-401-x19
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Supplier
- Rockland
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原理
- p62 Phospho T269/Ser272 Antibody
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交叉反应 （详细）
- Anti-Phospho-Thr269/Ser272 p62 Antibody is directed against p62 protein phosphorylated at T269 and S272.
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纯化方法
- The antibody was prepared from monospecific antiserum by immunoaffinity chromatography using phospho peptide coupled to agarose beads followed by solid phase adsorption(s) against non-phospho peptide and non-specific peptide to remove any unwanted reactivities.
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过滤
- Sterile filtered
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免疫原
- Anti-Phospho-Thr269/Ser272 p62 Antibody was produced in rabbits by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Thr269/Ser272 of human p62 conjugated to KLH.
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亚型
- IgG
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anti-Sequestosome 1 (SQSTM1) antibody
KO Validated SQSTM1 适用: 人 WB, IF, IP, FACS, ICC, IHC (p), PLA 宿主: 兔 Polyclonal unconjugated
anti-Sequestosome 1 (SQSTM1) (AA 51-150) antibodySQSTM1 适用: 人, 小鼠, 大鼠, Cow WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Sequestosome 1 (SQSTM1) (AA 1-440) antibodySQSTM1 适用: 人 WB, IF, ELISA 宿主: 小鼠 Monoclonal 2C11 unconjugated
anti-Sequestosome 1 (SQSTM1) (AA 1-440) antibodySQSTM1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Sequestosome 1 (SQSTM1) (AA 232-356) antibodySQSTM1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5H7E2 unconjugated
anti-Sequestosome 1 (SQSTM1) (AA 317-346) antibodySQSTM1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB4614 unconjugated
anti-Sequestosome 1 (SQSTM1) (AA 136-400) antibodySQSTM1 适用: 人 WB, IHC, IP, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sequestosome 1 (SQSTM1) (C-Term) antibodySQSTM1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Sequestosome 1 (SQSTM1) antibodySQSTM1 适用: 人, 猴 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 5A2 unconjugated
anti-Sequestosome 1 (SQSTM1) antibodyKO Validated SQSTM1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated
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应用备注
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ELISA_Dilution: 1:10,000
Western_Blot_Dilution: 1:1000
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说明
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Anti-Phospho-Thr269/Ser272 p62 Antibody is tested for Western Blots and is specific for the ~62 kDa p62 protein phosphorylated at Thr269 and Ser272. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
Preservative: None -
储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
- Store vial at -20° C prior to opening in undiluted aliquots. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
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有效期
- 12 months
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- SQSTM1 (Sequestosome 1 (SQSTM1))
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别名
- SQSTM1
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背景
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Synonyms: Sequestosome-1, EBI3-associated protein of 60 kDa, EBIAP, p60, Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, Ubiquitin-binding protein p62
Background: p62, also known as sequestosome1 (SQSTM1), is a shuttle protein transporting polyubiquitinated proteins for both proteasomal and lysosomal degradation. p62 is an integral component of inclusions in brains of various neurodegenerative disorders, including Alzheimer disease (AD) neurofibrillary tangles (NFTs) and Lewy bodies in Parkinson disease. p62 plays an important role in the protection of cells from the toxicity of misfolded proteins by enhancing aggregate formation especially in the later stages. Phosphorylation of Ser28 has recently been demonstrated to be related to the pathogenesis of Parkinson's disease. p62 pT269/pS272 Antibody is ideal for researchers interested in neuroscience research.
Gene Name: SQSTM1
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基因ID
- 8878
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NCBI登录号
- NP_003891
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UniProt
- Q13501
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途径
- NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy
抗原
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