DS-PB-01970 is specific for mouse Toll-like receptor 7 (TLR7). TLR7 is thought to play a role in the innate immune response to viral pathogens. Mouse TLR7 is localized in endosomal compartments, and recognises single stranded RNA viruses. Stimulation of TLR7 causes a type I IFN response, in a MyD88 dependent pathway.
交叉反应
人
纯化方法
Purified
免疫原
Antisera to mouse TLR7 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.