Presenilin 2 抗体
Quick Overview for Presenilin 2 抗体 (ABIN636358)
抗原
See all Presenilin 2 (PSEN2) 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Purified
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应用备注
- Optimal conditions should be determined byt he investigator.
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限制
- 仅限研究用
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浓度
- Lot specific
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注意事项
- Avoid repeated freeze/thaw cycles.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage.
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- Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))
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别名
- Presenilin 2
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背景
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP.
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途径
- Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
抗原
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