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CIC 抗体

CIC 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6292681
发货至: 中国
  • 抗原 See all CIC 抗体
    CIC (Capicua Homolog (CIC))
    适用
    • 34
    • 28
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    小鼠
    宿主
    • 44
    克隆类型
    • 44
    多克隆
    标记
    • 15
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This CIC antibody is un-conjugated
    应用范围
    • 19
    • 18
    • 13
    • 13
    • 13
    • 7
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein of human CIC
    亚型
    IgG
    Top Product
    Discover our top product CIC Primary Antibody
  • 应用备注
    WB 1:200 - 1:2000
    说明

    Expressed in fetal brain

    限制
    仅限研究用
  • 缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20C. Avoid freeze / thaw cycles.
  • 抗原
    CIC (Capicua Homolog (CIC))
    别名
    CIC (CIC 产品)
    别名
    wu:fb93c01 antibody, CIC antibody, 1200010B10Rik antibody, mKIAA0306 antibody, capicua transcriptional repressor b antibody, capicua transcriptional repressor antibody, cicb antibody, CIC antibody, Cic antibody
    背景
    The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
    分子量
    163.82 kDa
    基因ID
    23152
    UniProt
    Q96RK0
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