CIC 抗体
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- 抗原 See all CIC 抗体
- CIC (Capicua Homolog (CIC))
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CIC antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human CIC
- 亚型
- IgG
- Top Product
- Discover our top product CIC Primary Antibody
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- 应用备注
- WB 1:200 - 1:2000
- 说明
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Expressed in fetal brain
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20C. Avoid freeze / thaw cycles.
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- 抗原
- CIC (Capicua Homolog (CIC))
- 别名
- CIC (CIC 产品)
- 别名
- wu:fb93c01 antibody, CIC antibody, 1200010B10Rik antibody, mKIAA0306 antibody, capicua transcriptional repressor b antibody, capicua transcriptional repressor antibody, cicb antibody, CIC antibody, Cic antibody
- 背景
- The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
- 分子量
- 163.82 kDa
- 基因ID
- 23152
- UniProt
- Q96RK0
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