-
- 抗原 See all RANKL (TNFSF11) 抗体
- RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This RANKL antibody is un-conjugated
-
应用范围
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human TNFSF11
- 亚型
- IgG
- Top Product
- Discover our top product TNFSF11 Primary Antibody
-
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 221-300) antibody
TNFSF11 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 74-308) antibodyTNFSF11 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 8A7B9 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 10-90) antibodyTNFSF11 适用: 人, 小鼠 WB, ELISA, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 74-308) antibodyTNFSF11 适用: 人 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 3H8A7 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 210-317) antibodyTNFSF11 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (C-Term) antibodyTNFSF11 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 78-317) antibodyTNFSF11 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 74-308) antibodyTNFSF11 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 7G3D7 unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 92-263) antibodyTNFSF11 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 106-240) antibodyTNFSF11 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
IHC 1:50 - 1:200
IF 1:50 - 1:200 - 说明
-
Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid
- 限制
- 仅限研究用
-
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20C. Avoid freeze / thaw cycles.
-
- 抗原
- RANKL (TNFSF11) (Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11))
- 别名
- TNFSF11 (TNFSF11 产品)
- 别名
- CD254 antibody, ODF antibody, OPGL antibody, OPTB2 antibody, RANKL antibody, TRANCE antibody, hRANKL2 antibody, sOdf antibody, TNFSF11 antibody, Ly109l antibody, OPG antibody, Trance antibody, cd254 antibody, odf antibody, opgl antibody, optb2 antibody, rankl antibody, sodf antibody, tnfsf11 antibody, trance antibody, TNF superfamily member 11 antibody, tumor necrosis factor (ligand) superfamily, member 11 antibody, TNF receptor superfamily member 11b antibody, TNF superfamily member 11 L homeolog antibody, TNFSF11 antibody, Tnfsf11 antibody, TNFRSF11B antibody, tnfsf11.L antibody
- 背景
- This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
- 分子量
- 35.478 kDa
- 基因ID
- 8600
- UniProt
- O14788
- 途径
- NF-kappaB Signaling
-
You are here:
