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- 抗原 See all Selenoprotein N (SELENON) products
- Selenoprotein N (SELENON)
- 适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Selenoprotein N antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Affinity purification
- 免疫原
- Recombinant protein of human SEPN1
- 亚型
- IgG
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anti-Selenoprotein N (SELENON) antibody
SELENON 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Selenoprotein N (SELENON) (AA 135-219) antibodySELENON 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500 - 1:2000
- 说明
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Isoform 1 and isoform 2 are expressed in skeletal muscle, brain, lung and placenta, Isoform 2 is also expressed in heart, diaphragm and stomach
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20C. Avoid freeze / thaw cycles.
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- 抗原
- Selenoprotein N (SELENON)
- 别名
- SELENON (SELENON 产品)
- 背景
- This gene encodes a glycoprotein that is localized in the endoplasmic reticulum. It plays an important role in cell protection against oxidative stress, and in the regulation of redox-related calcium homeostasis. Mutations in this gene are associated with early onset muscle disorders, referred to as SEPN1-related myopathy. SEPN1-related myopathy consists of 4 autosomal recessive disorders, originally thought to be separate entities: rigid spine muscular dystrophy (RSMD1), the classical form of multiminicore disease, desmin related myopathy with Mallory-body like inclusions, and congenital fiber-type disproportion (CFTD). This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A second stop-codon redefinition element (SRE) adjacent to the UGA codon has been identified in this gene (PMID:15791204). SRE is a phylogenetically conserved stem-loop structure that stimulates readthrough at the UGA codon, and augments the Sec insertion efficiency by SECIS. Alternatively spliced transcript variants have been found for this gene.
- 分子量
- 65.813 kDa
- 基因ID
- 57190
- UniProt
- Q9NZV5
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